Three Distinct Types of Ca 2+ Waves in Langendorff-Perfused Rat Heart Revealed by Real-Time Confocal Microscopy
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منابع مشابه
Three distinct types of Ca(2+) waves in Langendorff-perfused rat heart revealed by real-time confocal microscopy.
Although Ca(2+) waves in cardiac myocytes are regarded as arrhythmogenic substrates, their properties in the heart in situ are poorly understood. On the hypothesis that Ca(2+) waves in the heart behave diversely and some of them influence the cardiac function, we analyzed their incidence, propagation velocity, and intercellular propagation at the subepicardial myocardium of fluo 3-loaded rat wh...
متن کاملThree Distinct Types of Ca Waves in Langendorff-Perfused Rat Heart Revealed by Real-Time Confocal Microscopy
Although Ca waves in cardiac myocytes are regarded as arrhythmogenic substrates, their properties in the heart in situ are poorly understood. On the hypothesis that Ca waves in the heart behave diversely and some of them influence the cardiac function, we analyzed their incidence, propagation velocity, and intercellular propagation at the subepicardial myocardium of fluo 3–loaded rat whole hear...
متن کاملMultinuclear NMR studies of the Langendorff perfused rat heart.
The quantitation of intracellular sodium ion concentration [Na+]in perfused organs using NMR spectroscopy requires a knowledge of the extent of visibility of the 23Na resonance and of the intracellular volume of the organ. We have used a multinuclear NMR approach, in combination with the extracellular shift reagent dysprosium (III) tripolyphosphate, to determine the NMR visibility of intra- and...
متن کاملHydrolysis of Ca -sensitive fluorescent probes by perfused rat heart
Scaduto, Russell C., Jr., and Lee W. Grotyohann. Hydrolysis of Ca2 -sensitive fluorescent probes by perfused rat heart. Am J Physiol Heart Circ Physiol 285: H2118–H2124, 2003; 10.1152/ajpheart.00881.2001.—Rat hearts were loaded with the fluorescent calcium indicators fura 2, indo 1, rhod 2, or fluo 3 to determine cytosolic calcium levels in the perfused rat heart. With fura 2, however, basal ti...
متن کاملOptical mapping of Langendorff-perfused rat hearts.
Optical mapping of the cardiac surface with voltage-sensitive fluorescent dyes has become an important tool to investigate electrical excitation in experimental models that range in scale from cell cultures to whole-organs([1, 2]). Using state-of-the-art optical imaging systems, generation and propagation of action potentials during normal cardiac rhythm or throughout initiation and maintenance...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2000
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.86.10.1093